Search results for "Imagerie Multimodale"
showing 5 items of 5 documents
Porphyrines et tétraazamacrocycles dérivés du DOTA : association de deux ligands pour la chélation de métaux d'intérêt en imagerie médicale multimoda…
2012
The goal of my PhD thesis was to synthesize new molecules, which give access to heterobimetallic complexes with interesting properties for multimodal imaging. In this manuscript, several main points have been studied. The first part of this work concerns the synthesis and characterization of ligands. We describe here the synthesis of five new ligands based on the association of one porphyrin and one or several cyclen derivatives. Those ligands are water-soluble. During the synthesis, we have targeted improvements to our work and developed a new synthetic pathway, which allowed us to obtain one ligand incorporating a porphyrin, a cyclen derivative and a free amine function. This function cou…
Study of new tellurite glasses in the TeO2-ZnO-La2O3 (TZL) system for the manufacturing of mid-infrared multimaterial optical fibers and specialty op…
2023
This thesis work was carried out using tellurite glasses from the TeO2-ZnO-La2O3 (TZL) ternary diagram for optical fibers manufacturing. The choice to use this system is motivated by the ambition to improve the transmission of optical signals within oxide glasses for which absorption bands related to OH groups are present in the transparency window. A structural study is first carried out on these glasses by Raman spectroscopy in order to understand the influence of the composition on physicochemical properties (especially on optical and thermal properties) but also to estimate the ability of a vitreous matrix to reorganize when subjected to a thermal solicitation such as the preform-to-fib…
Synthesis and study of new fluorescent probes for optical imaging, Cherenkov imaging and multimodal imaging
2015
The goal of this work was to prepare and study new fluorescent probes, which could give rise to novel optical or Cherenkov imaging agents. The first section of this work describes the synthesis of fluorescent subphthalocyanines and phthalocyanines probes, which possess relevant chemicals groups suitable for optical imaging applications. The optical and physico-chemical properties of the new probes were carefully examined to ensure they comply with the specification of the fluorophores for the desired application. The second part focused on the subsequent development of a few selected probes into real imaging agents. The biovectorisation of subphtalocyanines was achieved upon conjugation of …
Iron oxides nanoparticles and titanate nanotubes dedicated to multimodal imaging and anticancer therapy
2013
The new implementations of nanoparticles in the medical field are one of the essential factors of the medical progress expected at the beginning of this XXIst century. Thus, the domain of the medical imaging is also affected by this technological evolution. This work consisted in developing theranostic probes with iron oxides nanoparticles (SPIO) and titanate nanotubes (TiONts) for multimodal imaging (magnetic/nuclear or magnetic/optical) and also possessing a therapeutic effect (hyperthermia/PDT or radiosensitization/PDT).The titanate nanotubes of this study have an average length of about 150 nm and were obtained by Kasuga's hydrothermal synthesis. These nanotubes present an outside diame…
Fiber-based light source for biomedical applications
2013
This manuscript presents the work done concerning the development of a light source used for biomedical imaging and more particularly for coherent Raman scattering imaging. In fact an efficient broadcasting of these ones is hampered by the need of two synchronized and wavelength shifted pulses. As so, the handiness and frequency conversion capabilities of nonlinear fiber optics are used to circumvent this technological lock. First of all, an easy wavelength tunable source is set by the use of the self-shifting in optical frequency of a soliton. A study of the main fiber parameters lead to shifts of 320 to more than 500 nm which allows interesting molecular resonances imaging (≈ 1000-4000 cm…